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In addition, inflammation itself produces large quantities of reactive species, and a destructive cycle can be perpetuated

Curiously, dopamine-producing neurons outside of the SN tend not to be affected, though many other neuronal types glutamatergic, cholinergic, tryptaminergic, GABAergic, noradrenergic, adrenergic show grievous cytoskeletal damage, according to Braak and Braak

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Lim JE, Lee S, Lee S, Jee SH

Optimal cut points of plasma and urine neutrophil gelatinase-associated lipocalin for the prediction of acute kidney injury among critically ill adults: retrospective determination and clinical validation of a prospective multicentre study